Objectives. After 10 years of worldwide awareness of beneficial effects of Matridermu00ae for operative treatment of 3rd degree burns, we finally have the opportunity to use it in our everyday practice. First results seem to be encouraging and we present our two cases.Methods. We used Matridermu00ae for the first time in a 53-year-old female who sustained a 3rd degree scald burn of the lower leg. After necrectomy, it was evident that problematic regions were the popliteal area and denuded portion of the Achilles tendon in the extent of 7 cm. Necrectomy encompassed the entire posterior area of the lower leg. One sheet of a 1 mm thick Matridermu00ae was used and covered with a STSG meshed graft (1 :1.5), and then dressed with Vaseline gauze and hydrofiber dressing enriched with silver. In our second case, we used Matridermu00ae in a 64-year-old female who sustained a 3rd degree scald burn in the Achilles tendon region. After necrectomy, there was a 5 cm large denuded portion of the Achilles tendon, so we also applied 1 mm thick Matriderm, covered it with a STSG and dressed it in the same way as in the first case.Results. First control showed excellent take in both cases. In the first case, only a minor area above the tendon was problematic, so we decided to treat it with hemoglobin spray and NPWT during 4 weeks. With early physical therapy, range of motion was more than satisfying, as well as aesthetic results. Conclusion. In comparison to using only STSG, the use of Matridermu00ae in the treatment of 3rd degree burns for very demanding areas resulted in better aesthetic and functional outcomes. The main advantage was its compatibility with other supporting methods such as NPWT.