Lead Molecules from Natural Products

This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design.

Author:

Publisher: Elsevier

ISBN: 9780080459332

Category: Science

Page: 448

View: 299

Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered. The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations. * Explains the effects of plant extracts on gene expression profiling. * Details medicinal plant research from around the world * Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.

Recent Advances in Natural Products Analysis

I am honored and humbled being invited to write the preface of the book, Recent Advances in Natural Products Analysis (publisher: ... Natural products have been playing a pivotal role not only in the discovery of several modern drugs, ...

Author: Seyed Mohammad Nabavi

Publisher:

ISBN: 0128164557

Category: Science

Page: 878

View: 380

Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included. Focuses on the latest analytical techniques used for studying phytochemical and other biological compounds Authored and edited by the top worldwide experts in their field Discusses the current and potential applications and predicts future trends of each compound group

Plant derived Natural Products

In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural ...

Author: Anne E. Osbourn

Publisher: Springer Science & Business Media

ISBN: 9780387854984

Category: Science

Page: 597

View: 803

Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Pharmacological Advances in Natural Product Drug Discovery

Pharmacological Advances in Natural Product Drug Discovery, Volume 87 in the Advances in Pharmacology series, presents the latest pharmacological research progresses of 8 medicinal compounds from natural products, including salvianolic acid ...

Author: Guanhua Du

Publisher: Academic Press

ISBN: 0128201851

Category:

Page: 312

View: 285

Pharmacological Advances in Natural Product Drug Discovery, Volume 87 in the Advances in Pharmacology series, presents the latest pharmacological research progresses of 8 medicinal compounds from natural products, including salvianolic acid, tanshinone, paeonol, chlorogenic acid, astragaloside, icariin, ganoderan, and febrifugine. Specific chapters to this new release include Potential Role of Paeonol on Atherosclerosis Related Cells, A Review on Salvianolic Acid, Pharmacological Advances of Tanshinones, the Natural Product of Salvia Miltiorrhiza, Pharmacological Action and Potential Targets Analysis of Major Pharmacological Effects of Chlorogenic Acid, Modern TCM: Identifying and Defining the "Medicinal Mix", Pharmacological Advances in Astragaloside IV Derived from Astragalus Membranaceus, and much more. Includes the authority and expertise of leading contributors in natural product pharmacology Provides the latest pharmacological research progresses of eight medicinal compounds from natural products Presents a thorough discussion on the compatibility of traditional medicines

Natural Products

The volume is comprehensive in its treatment of biologically based products in the natural world. Natural Products: Discourse, Diversity, and Design will be a vital resource for anyone working in this rapidly developing field.

Author: Anne Osbourn

Publisher: John Wiley & Sons

ISBN: 1118794605

Category: Science

Page: 552

View: 582

Natural Products: Discourse, Diversity andDesign provides an informative and accessible overview ofdiscoveries in the area of natural products in the genomic era,bringing together advances across the kingdoms. As genomicsdata makes it increasingly clear that the genomes of microbes andplants contain far more genes for natural product synthesis thanhad been predicted from the numbers of previously identifiedmetabolites, the potential of these organisms to synthesize diversenatural products is likely to be far greater than previouslyenvisaged. Natural Products addresses notonly the philosophical questions of the natural role of thesemetabolites, but also the evolution of single and multiplepathways, and how these pathways and products may be harnessed toaid discovery of new bioactives and modes of action. Edited by recognized leaders in the fields of plant andmicrobial biology, bioorganic chemistry and natural productschemistry, and with contributions from researchers at top labsaround the world, Natural Products isunprecedented in its combination of disciplines and the breadth ofits coverage. Natural Produces: Discourse, Diversity andDesign will appeal to advanced students andexperienced researchers, from academia to industry, in diverseareas including ecology, industrial biotechnology, drug discovery,medicinal chemistry, agronomy, crop improvement, and naturalproduct chemistry.

Discovery and Development of Anti inflammatory Agents from Natural Products

Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug ...

Author: Goutam Brahmachari

Publisher: Elsevier

ISBN: 0128169931

Category: Science

Page: 332

View: 750

Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Genome Mining and Synthetic Biology in Marine Natural Products Discovery

Helfrich, E.J.N.; Reite, S.; Piel, J. Recent advances in genome-based polyketide discovery. Curr. Opin. Biotechnol. 2014, 29, 107–115. ... Zerikly, M.; Challis, G.L. Strategies for the discovery of new natural products by genome mining.

Author: Maria Costantini

Publisher: MDPI

ISBN: 3036502548

Category: Science

Page: 92

View: 577

In recent years, marine genomics has become a rapidly growing field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth’s surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs.

Advances in Natural Products Discovery

In this context, this book highlights some of the most recent advances in natural product discovery over the past few years.

Author: Ana Rita Gomes

Publisher: Nova Publishers

ISBN: 9781536101010

Category: MEDICAL

Page: 309

View: 176

The largely unexplored natural world harbors great biodiversity, and provides a unique and rich source of natural products with interesting pharmaceutical activities as well as potential applications for environmental protection. Over the last few years, much attention has been paid to unraveling the structural, compositional and sequential properties of bioactive compounds, but the exploration of new natural resources needs to be developed wisely while keeping sustainability principles in mind. With the help of some developed isolation techniques, researchers have been able to elucidate new extraction methods applicable to both aquatic and terrestrial organisms. Natural products have often been used in medicine, food, fragrances, and pest control. Most likely due to their easy accessibility, terrestrial plants have been the major source of medicinal products, especially for traditional or folk medicine. However, only 10% of over 250,000 plants have been investigated for biological activity. On the other hand, aquatic environments contain over 80% of world's plant and animal species. In recent years, several bioactive compounds have been extracted from various marine organisms, such as tunicates, sponges, starfish, soft corals, bryozoans, and sea cucumbers, among others. The search for new metabolites from marine organisms has resulted in the isolation of more than 10,000 metabolites, many of which are endowed with pharmacodynamic properties. These natural products are of high commercial value due to their natural source, complete biodegradable properties, lower or no toxicity, and in most cases lower cost compared to synthetic chemicals. Despite the biodiversity in the marine environment overcoming that of the terrestrial environment, the research into the use of natural marine products as pharmaceutical agents and for environmental applications is still in its early stages. In this context, this book highlights some of the most recent advances in natural product discovery over the past few years.

Advances in Drug Discovery Techniques

A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery.

Author: Alan L. Harvey

Publisher: CRC Press

ISBN: 9780471975090

Category: Medical

Page: 222

View: 817

A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.

13C NMR of Natural Products

Advances in natural product chemistry have led to a large number of drugs, both derived from medicinal plants, marine plants, and animals, and created as synthetic analogues of these sources.

Author: Atta-Ur-Rahman

Publisher: Springer Science & Business Media

ISBN: 9780306438974

Category: Science

Page: 966

View: 768

Advances in natural product chemistry have led to a large number of drugs, both derived from medicinal plants, marine plants, and animals, and created as synthetic analogues of these sources. This ground-breaking, comprehensive volume presents the latest data on the 13C-NMR of monoterpenes and sesquiterpenes.