Principles of Cancer Biology

KEY concepts BUILD AstroNG Foundation FOR YOUR STUDY OF CANCER BIOLOGY Principles of Cancer Biology is an engaging book focused on providing a "big picture" view that emphasizes the key concepts of cancer biology for both students and a ...

Author: Lewis J. Kleinsmith

Publisher: Pearson

ISBN:

Category: Health & Fitness

Page: 348

View: 312

Principles of Cancer Biology, is an engaging book focused on providing readers with a "big picture" view of cancer. Author Lewis Kleinsmith has written an instructional text focusing on key concepts for a general audience. Each chapter contains a list of suggested readings that expand the detail as needed. The text also emphasizes the scientific evidence that underlies cancer biology, and teaches readers to think critically about this evidence- as there are constantly new "breakthroughs" and reports in this field. For readers who need the review, there are brief reviews of several topics related to DNA replication and repair, cell division, cell signaling, and inheritance patterns in chapters where these subjects are relevant. By including these reviews, the text is both accessible and engaging to a broad audience of readers who are studying cancer biology for the first time, as well as an interested general audience. What Is Cancer, Profile of a Cancer Cell, How Cancers Spread, Identifying the Causes of Cancer, Chemicals and Cancer, Radiation and Cancer, Infectious Agents and Cancer, Heredity and Cancer, Oncogenes, Tumor Suppressor Genes and Cancer Overview, Cancer Screening, Diagnosis, and Treatment, Preventing Cancer, Main Types of Cancer, Human Carcinogens. For all readers interested in the big picture view of cancer.

Cancer Research

r MC American Association for Cancer Research CENTENNIAL 1 207 2007 AACR Cancer Research Funding Available Open to young investigators , AACR Career Development Awards , Fellows Grants and Research Fellowships provide the funding ...

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Category: Cancer

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Cancer Biology

The development of a large, complex ge- nome of WHAT SIGNIFICANT EVENTS HAVE up to 40,000 genes that must be replicated perfectly every time a cell di- HAPPENED IN CANCER RESEARCH IN THE LAST 25 YEARS? vides. 4.

Author: Raymond W. Ruddon M.D.

Publisher: Oxford University Press

ISBN: 0199748152

Category: Medical

Page: 568

View: 115

A thorough yet concise account of cancer biology, this book emphasizes the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It also defines the fundamental pathophysiological changes that occur in tumor tissue and in the host animal or patient. The approach throughout the book is to discuss the historical development of a field, citing the key experimental advances to the present day, and to evaluate the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made to relate basic research findings to the clinical disease states. The book is well illustrated with schematic diagrams and actual research data to demonstrate points made in the text, and there is an extensive, up-to-date bibliography. In this revision, Dr. Ruddon has organized his text to provide more integrated discussion of the many topics covered in the third edition. At the same time, he has included much new material on molecular genetics and genetic diagnosis (e.g., DNA microarrays to mark tumors), RNA interference, stem cells, cell cycle regulation, angiogenesis, etc.


Hyaluronan in Cancer Biology

Hyaluronidases in Cancer Biology ROBERT STERN Introduction 207 Hyaluronidases and Their Structure 209 A Catabolic Scheme for Hyaluronan 210 The Warburg Effect 210 Hyaluronidase Inhibitors 212 Hyaluronidase Modulates CD44 Expression 213 ...

Author: Robert Stern

Publisher: Academic Press

ISBN: 9780080921082

Category: Medical

Page: 468

View: 507

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. * Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer * Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination * Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

Translation and Its Regulation in Cancer Biology and Medicine

The past 20 years of research on the association of eIF4E with cancer have yielded a vast amount of knowledge and cemented eIF4E as a critical player in cancer biology. Its expression and availability represent important biomarkers for ...

Author: Armen Parsyan

Publisher: Springer

ISBN: 9401790787

Category: Medical

Page: 697

View: 701

This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia. The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.

Recent Advances in Cancer Research

Cell Biology, Molecular Biology, and Tumor Virology Robert C. Gallo. control of cell growth, at least one other system of growth control seems necessary. This system of growth control would act as an overall permissive gate, ...

Author: Robert C. Gallo

Publisher:

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Category: Cancer cells

Page: 290

View: 708


Directory of Cancer Research Information Resources

Distribution : Available to biomedical research community upon written request . Ordering instructions : Contact Mr. Greenberg at the address above . Cost : Free of charge . 590 * DIVISION OF CANCER BIOLOGY AND DIAGNOSIS PROGRAM REPORTS ...

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Category: Cancer

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Available cancer information sources throughout the world. Includes publications, libraries, classification schemes, audiovisual sources, cancer registries, special collections, projects information sources, organizations, and government agencies. Classified arrangement. Each entry gives descriptive and contact information. Title, organization, geographical, and subject indexes. Bibliography of 99 references.

Advances in Cancer Research

... Heston The Structure and Function of Intercellular Junctions in Cancer Ronald S. Weinstein, Frederick B. Merk, and Joseph Alroy Genetics of Adenoviruses Harold S. Ginsberg and C. S. H. Young Molecular Biology of the Carcinogen, ...

Author: Jesse Philip Greenstein

Publisher:

ISBN:

Category: Cancer

Page: 432

View: 728