Cellular Oscillatory Mechanisms

Oscillatory dynamics are a central feature of a wide range of biological processes. This text fully explores cellular oscillations, focusing particularly on elucidating the basic mechanisms that underlie these oscillations.

Author: Miguel Maroto

Publisher: Springer Science & Business Media

ISBN: 0387097945

Category: Medical

Page: 153

View: 451

Oscillatory dynamics are a central feature of a wide range of biological processes. This text fully explores cellular oscillations, focusing particularly on elucidating the basic mechanisms that underlie these oscillations.

Biochemical Oscillations and Cellular Rhythms

This book addresses the molecular bases of some of the most important biochemical rhythms known at the cellular level.

Author: Albert Goldbeter

Publisher: Cambridge University Press

ISBN: 0521403073

Category: Science

Page: 632

View: 385

This book addresses the molecular bases of some of the most important biochemical rhythms known at the cellular level. Clarifying the mechanism of these oscillatory phenomena is of key importance for understanding the origin as well as the physiological function of these rhythms, and the conditions in which simple periodic behaviour transforms into complex oscillations, including bursting and chaos. The approach rests on the analysis of theoretical models closely related to experimental observations. Among the main rhythms considered are glycolytic oscillations observed in yeast and muscle, oscillations of cyclic AMP in Dictyostelium amoebae, intracellular calcium oscillations observed in a variety of cell types, the mitotic oscillator that drives the cell division cycle in eukaryotes, and circadian oscillations of the period protein (PER) in Drosophila. For each of these phenomena, experimental facts are reviewed and mathematical models presented.

Molecular and Cellular Mechanisms in Reproduction and Early Development

The fertilization of a mammalian egg involves a series of low frequency Ca2+ oscillations that last for many hours. Such Ca2+ oscillations play the key role in egg activation and the subsequent development of the embryo (Stricker, ...

Author: Rafael A. Fissore

Publisher: Frontiers Media SA

ISBN: 2889459446


Page: 145

View: 410

The Research Topic aims to support progress towards understanding the different sets of developmental processes that are absolutely required to complete all the steps essential for successful embryonic development, under physiological conditions. We sought contributions that dealt with single cells, interaction between cells as well as intra- and extracellular signal transduction. The Research Topic presents original studies covering experimental and theoretical approaches, descriptions of new methodologies, reviews and opinions.


A major task was to explore the cellular mechanisms that underlie the recently discovered slow oscillation ( less than ... these two oscillatory types is emphasized because of their distinct origins and mechanisms ( the slow oscillation ...

Author: Ernst Niedermeyer

Publisher: Lippincott Williams & Wilkins

ISBN: 9780781751261

Category: Medical

Page: 1342

View: 405

Established in 1982 as the leading reference on electroencephalography, Drs. Niedermeyer's and Lopes da Silva's text is now in its thoroughly updated Fifth Edition. An international group of experts provides comprehensive coverage of the neurophysiologic and technical aspects of EEG, evoked potentials, and magnetoencephalography, as well as the clinical applications of these studies in neonates, infants, children, adults, and older adults. This edition includes digital EEG and advances in areas such as neurocognition. Three new chapters cover the topics of Ultra-Fast EEG Frequencies, Ultra-Slow Activity, and Cortico-Muscular Coherence. Hundreds of EEG tracings and other illustrations complement the text.

Jasper s Basic Mechanisms of the Epilepsies

intrinsic mechanism that may act as a secondary oscillator supporting slow rhythm.80 Cortical activity can recruit, ... isolated neocortical slabs.85 Little is known about the cellular mechanisms mediating cortical delta oscillation.

Author: Jeffrey Noebels

Publisher: Oxford University Press

ISBN: 0199842590

Category: Medical

Page: 1264

View: 249

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Cell Division Control in Plants

1 Introduction and Background Progression through the eukaryotic cell cycle is controlled by several mechanisms whose activity varies periodically with cell cycle phase. These oscillating regulatory mechanisms are involved in ...

Author: Desh Pal S. Verma

Publisher: Springer Science & Business Media

ISBN: 3540734872

Category: Science

Page: 417

View: 452

This volume examines the molecular basis of all aspects of cell division and cytokinesis in plants. It features 19 chapters contributed by world experts in the specific research fields, providing the most comprehensive and up-to-date knowledge on cell division control in plants. The editors are veterans in the field of plant molecular biology and highly respected worldwide.

Temporal Disorder in Human Oscillatory Systems

They entrain the endogenous circadian oscillation of organisms to exactly 24 h, or perturb (phase shift) the oscillation in cases of transmeridian ... If they have similar effects, what is the common cellular mechanism of their effects?

Author: Ludger Rensing

Publisher: Springer Science & Business Media

ISBN: 3642726372

Category: Science

Page: 259

View: 147

Rhythms of the heart and of the nervous and endocrine system, breathing, locomotory movements, sleep, circadian rhythms and tissue cell cycles are major elements of the temporal order of man. The dynamics of these systems are characterized by changes in the properties of an oscillator, transitions from oscillatory states into chaotic or stationary states, and vice versa, coupling or uncoupling between two or more oscillators. Any deviation from the normal range to either more or less ordered states may be defined as temporal disorder. Pathological changes of temporal organization, such as tremor, epileptic seizures, Cheyne-Stokes breathing, cardiac arrhythmicities and circadian desynchronization, may be caused by small changes in the order (control) parameters. One major aspect of the symposium was the analysis of characteristic features of these temporal control systems, including nonlinear dynamics of interactions, positive, negative and mixed feedback systems, temporal delays, and their mathematical description and modelling. The ultimate goal is a better understanding of the principles of temporal organization in order to treat periodic diseases or other perturbations of "normal" dynamics in human oscillatory systems.

Calcium Regulation of Cellular Function

One popular hypothesis is that the waves and oscillations are a way of encoding information in a ... behavior is observed in many different cell types, it is likely that the responsible mechanisms differ from one cell type to another.


Publisher: Academic Press

ISBN: 9780080552736

Category: Science

Page: 416

View: 324

Volume 30 examines the prominent role of calcium as an intracellular second messenger. Leading investigators review a wide variety of studies on how calcium enters and moves through cells, how it interacts with its many binding proteins, and how calcium and its intracellular receptor, calmodulin, control vital cellular processes. Coverage includes a detailed analysis of the mechanisms by which calcium bound to calmodulin regulates contractile proteins in smooth muscle cells. Close attention is given to the roles of calcium and calmodulin-dependent protein kinases and phosphatases in synaptic signal transduction, protein synthesis, gene expression, programmed cell death, activation of T-lymphocytes, and control of cell division cycles. Other chapters discuss studies using genetically manipulable nonmammalian organisms to further proble the functions of calcium and calmodulin.

Microcirculation in Cardiovascular Diseases

The cellular mechanisms responsible for vasomotion involve both an oscillator, which sets up an oscillation of tone in ... muscle cell, and a mechanism that ensures synchronization of the smooth muscle cells oscillatory activity in the ...

Author: Enrico Agabiti-Rosei

Publisher: Springer Nature

ISBN: 3030478017

Category: Medical

Page: 216

View: 374

This book offers an extensive review of the most recent data on the pathophysiological role of structural and functional alterations in the microcirculation, particularly focusing on hypertension and diabetes. It covers several relevant and innovative aspects, including the possible mechanisms involved in the development of microvascular remodeling and rarefaction, the technical approaches available for the detection of microvascular alterations, including non-invasive evaluations, the prognostic role of changes in small resistance artery structure, the possibility of preventing or regressing such alterations with appropriate treatment, and the potential clinical advantages of such intervention. A number of innovative areas of research are considered, including the role of the immune system, inflammation and oxidative stress in the development of microvascular alterations. Lastly, it examines the availability of recent non-invasive methods for the evaluation of small resistance artery morphology in the retina, which in the near future may provide a useful tool for the stratification of cardiovascular risk and even for clinical decisions regarding drug treatment, thus providing physicians with a clinically relevant instrument for improving and optimizing the management of hypertensive and diabetic patients. The book provides valuable, clinically relevant information for specialists (cardiology, internal medicine, and endocrinology) and general practitioners, and also offers novel and stimulating data to basic and clinical researchers.