Dehydroepiandrosterone and Brain Aging

The work embodied in this book was carried out to find out whether administration of neuroprotective and anti-aging compound dehydroepiendrosterone (DHEA) at different ages of the animals prevents the delay of biochemical, molecular, ...

Author: Pardeep Kumar

Publisher: LAP Lambert Academic Publishing

ISBN: 9783846533895

Category:

Page: 108

View: 759

In recent years science and technology have made big steps, allowing us to greatly improve knowledge in basically every aspect of biology, culminating in the mapping of the human genome. However, although the brain is considered our most vital organ, the essence of personality and memory, much about the human brain still remains a mystery. Morphological analyses seemed to support the idea that senescence was accompanied by neuronal loss, particularly evident in the cortical and hippocampal structures. The work embodied in this book was carried out to find out whether administration of neuroprotective and anti-aging compound dehydroepiendrosterone (DHEA) at different ages of the animals prevents the delay of biochemical, molecular, structural and physiological alterations know to the neurological disease associated with aging. Based on study, the DHEA beneficial effects seemed to arise from their antioxidative, antiobesity, antilipofuscin and antilipidperoxidative actions.

DHEA in Human Health and Aging

Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes.

Author: Ronald Ross Watson

Publisher: CRC Press

ISBN: 1439838844

Category: Medical

Page: 472

View: 437

Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, an

DHEA and the Brain

DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans.

Author: Robert Morfin

Publisher: CRC Press

ISBN: 1134475756

Category: Medical

Page: 226

View: 988

DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans. Chapter authors evaluate DHEA metabolism in tissues and organs, explore DHEA effects in the liver that may be of importance to the brain, and discuss recent findings regarding how DHEA is made in the brain. New perspectives about the neuropro

Dehydroepiandrosterone DHEA and Aging

This volume discusses the molecular basis for age-dependent changes in DHEA levels with the aim of determining the potential value of DHEA as a diagnostic and therapeutic tool in age-related disorders.

Author: Francis L. Bellino

Publisher:

ISBN:

Category: Science

Page: 350

View: 215

This volume discusses the molecular basis for age-dependent changes in DHEA levels with the aim of determining the potential value of DHEA as a diagnostic and therapeutic tool in age-related disorders. It provides an overview of the biosynthesis and metabolic physiology of DHEA as well as of its biochemical modes of action and possible roles in the immunologic senescence and atherogenesis that are associated with aging. This book significantly furthers the understanding of the physiological role of DHEA throughout the aging process.

Dehydroepiandrosterone DHEA and DHEA Sulfate Roles in Brain Function and Disease

Among the neuroactive steroids, dehydroepiandrosterone (3b-hydroxyandrost-5-ene-17-one, [DHEA]) and its sulfated metabolite DHEA sulfate (DHEAS) have been shown to be potent modulators of neural function, including neurogenesis, neuronal ...

Author: Tracey A. Quinn

Publisher:

ISBN:

Category: Medicine

Page:

View: 347

Among the neuroactive steroids, dehydroepiandrosterone (3b-hydroxyandrost-5-ene-17-one, [DHEA]) and its sulfated metabolite DHEA sulfate (DHEAS) have been shown to be potent modulators of neural function, including neurogenesis, neuronal growth and differentiation, and neuroprotection. Highlighting the potential health significance of DHEA and DHEAS in humans, serum concentrations decrease steadily with age, with lowest concentrations present at the time many diseases of aging and neurodegeneration become apparent. This temporal association has led to the suggestion that pathology associated with cognitive decline, age-related neurological disorders such as Alzheimer's disease, dementia, amyotrophic lateral sclerosis (ALS), and adult onset schizophrenia may, in part at least, be attributed to decreased secretion of DHEA. Animal studies suggest neuroprotective functions for DHEA and DHEAS through reduction of glutamate-induced excitotoxicity. Reduced myelin loss and reactive gliosis after spinal cord injury by DHEA treatment also suggest a role for DHEA in the treatment of white matter pathologies such as multiple sclerosis. In this chapter, we discuss the physiological roles of DHEA and DHEAS in the central nervous system (CNS), their potential as neuroprotective hormones with reference to documented effects on excitotoxicity and oxidative stress, and their anti-glucocorticoid actions during chronic stress. The potential for metabolic derivatives of DHEA, such as estrogens and testosterone on brain function, and their contribution to neurodevelopment and neurodegenerative conditions are also discussed.


Hormones Gender and the Aging Brain

Written by an eminent team of psychiatrists, psychologists, geriatricians and neuropharmacologists, this book brings together established information and findings in four sections: • An overview of the basic science of neurosteroids • ...

Author: Mary F. Morrison

Publisher: Cambridge University Press

ISBN: 9781139426459

Category: Medical

Page: 359

View: 835

The significance of hormone action in psychiatry has been long studied, now including the psychiatric effects of hormones on the aging process. This clinical reference addresses the hormonal basis of mental disorders in older people. Hormones influence a wide range of states and conditions, from pain tolerance and anorexia to attention, mood, immunity, cardiovascular and cognitive function, schizophrenia and Alzheimer's disease. Written by an eminent team of psychiatrists, psychologists, geriatricians and neuropharmacologists, this book brings together established information and findings in four sections: • An overview of the basic science of neurosteroids • Sex difference and the roles that cortisol, thyroid hormone, and the sex steroids estrogen, progesterone, dehydroepiandrosterone and testosterone play in common mental disorders and pain sensitivity • Psychoneuroimmunology in relation to age • Sex differences and hormones in psychotropic drug metabolism in the elderly.

The Superhorme Promise

The best-selling authors of The Melatonin Miracle present new evidence that superhormones can control aging, arguing that DHEA and other hormones can boost the immune system, reduce body fat, maintain health, and reverse the aging process.

Author: William Regelson

Publisher: Simon and Schuster

ISBN: 0671010034

Category: Medical

Page: 400

View: 823

Argues that aging is a preventable disease and provides information on the research, benefits, and availability of superhormones.

Hormones in Neurodegeneration Neuroprotection and Neurogenesis

This book is written by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair.

Author: Achille G. Gravanis

Publisher: John Wiley & Sons

ISBN: 3527633979

Category: Science

Page: 404

View: 591

As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.

Neuroactive Steroids in Brain Function Behavior and Neuropsychiatric Disorders

This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders.

Author: Abraham Weizman

Publisher: Springer Science & Business Media

ISBN: 9781402068546

Category: Medical

Page: 564

View: 144

This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain. It also suggests possible therapeutic approaches to the use of natural occurring or sinthetic neurosteroids. The contributors suggest that neuroactive steroids could have a role in clinical practice.


DHEA and the Brain

... span and protects rats from age-related loss of cognitive functions: a benzodiazepine/GABAergic hypothesis of brain aging. Neurobiol. Aging, 15,69–84.

Author: Robert Morfin

Publisher: CRC Press

ISBN: 0203301218

Category: Medical

Page: 226

View: 905

DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans. Chapter authors evaluate DHEA metabolism in tissues and organs, explore DHEA effects in the liver that may be of importance to the brain, and discuss recent findings regarding how DHEA is made in the brain. New perspectives about the neuropro

Handbook of the Aging Brain

It has been postulated that dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) are markers of successful aging and life expectancy, whereas cortisol ...

Author: Eugenia Wang

Publisher: Elsevier

ISBN: 0080533221

Category: Science

Page: 263

View: 961

Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapters discuss the affect of aging on learning and memory, language, and cognition.

The DHEA Breakthrough

With this comprehensive, accessible book, you can look forward to a longer, more satisfying, more healthful life! "I've used DHEA in my practice for five years and seen how it can help restore physiologic balance.

Author: Stephen Cherniske

Publisher: Ballantine Books

ISBN: 0307775011

Category: Health & Fitness

Page: 368

View: 630

DO YOU WANT . . . The high energy you enjoyed in your twenties and thirties? Protection against cancer, heart disease, diabetes, and osteoporosis? Renewed sexual appetite and vigor? To beat depression, boost your memory, and handle stress? To lose body fat while building up your lean muscle mass? DHEA can do all this and more! In The DHEA Breakthrough, biochemist Stephen Cherniske gives you all the information you need to take advantage of and maximize the extraordinary properties of this superhormone--safely and effectively. The DHEA Breakthrough contains the easy-to-implement DHEA Plan, including a diet designed for our "paleolithic" bodies, stress reduction techniques, and an exercise program that eases you into the next level of performance, no matter where you are now. With this comprehensive, accessible book, you can look forward to a longer, more satisfying, more healthful life! "I've used DHEA in my practice for five years and seen how it can help restore physiologic balance. That's close to a modern day miracle, and this book describes the breakthrough perfectly." --Jesse Hanley, M.D., Medical Director, Malibu Health and Rehabilitation

Reversing Aging

In this context, especially the role of this book assumes special significance.

Author: Dr.Bruce Goldberg

Publisher: Pustak Mahal

ISBN: 9788122301113

Category:

Page: 224

View: 230

Add 15 to 50 years to your life, naturally! Yes, it is possible! Discover new meditative techniques, including self-hypnosis in this all new guide to Reversing Aging. Discover for yourself: *How to use self-hypnosis to increase the natural production of DHEA to slow down the aging process *How to look younger immediately *Easy techniques to boost your brain power and improve memory *An eating plan to reduce the cellular changes leading to old age symptoms *Nutritional keys to halt aging skin *Simple methods to significantly improve your sex life *Step-by-step plan to reprogram the internal computer that may be aging you prematurely *How to prolong a vibrant life by Reversing Aging The way the world populations are progressing, it is clear that in a few decades we will have a greater number of elderly people as compared to the young ones. In this context, especially the role of this book assumes special significance.

The Anti Aging Hormones

The Anti-Aging Hormones explores these questions and more: Which hormones can elevate mood and increase brain activity? Will growth hormones restore vigor and muscles in men?

Author: Ruth Winter

Publisher: Crown

ISBN: 0307829359

Category: Health & Fitness

Page: 292

View: 493

The quest for lasting youth, vigor, and sexual potency has reached a new frontier, and this fact-filled investigation, The Anti-Aging Hormones (Crown, 1997) discusses the latest results in clinical testing of hormones. Drawing on the most current research by the National Institute of Aging, nationally known health expert Ruth Winter investigates the uses and misuses of testosterone, melatonin, estrogen, and other manufactured hormones. Her book tackles the most challenging medical questions in a field that has captured the imagination of millions of aging baby boomers. The Anti-Aging Hormones explores these questions and more: Which hormones can elevate mood and increase brain activity? Will growth hormones restore vigor and muscles in men? Is melatonin the time keeper that determines how fast we age and how long we live? How effective are thymus gland hormones in immunizing us from infections and cancer? Can estrogen prevent Alzheimer's in both men and women?

Dehydroepiandrosterone DHEA

Neurobiol Aging 1994; 15(l):69-84 [235] Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, 3d, Araoz C: Brain interleukin 1 and S-100 ...

Author: Mohammed Kalimi

Publisher: Walter de Gruyter

ISBN: 3110811162

Category: Science

Page: 437

View: 772


Hormones Gender and the Aging Brain

This book brings together established information and recent findings in four sections: An overview of the basic science of neurosteroids Sex difference and the roles that cortisol, thyroid hormone, and the sex steroids estrogen, ...

Author: Mary F. Morrison

Publisher: Cambridge University Press

ISBN: 9780521653046

Category: Medical

Page: 378

View: 605

The significance of hormone action in psychiatry has long been studied, but only recently has this study included the psychiatric effects of hormones on the aging process. Hormones influence a wide scope of states and conditions, ranging from pain tolerance and anorexia to attention, mood, immunity, cardiovascular and cognitive function, schizophrenia, and Alzheimer's disease. Written by an eminent team of psychiatrists, psychologists, geriatricians, and neuropharmacologists, this pioneering clinical reference addresses the hormonal basis of mental disorders in older people. This book brings together established information and recent findings in four sections: An overview of the basic science of neurosteroids Sex difference and the roles that cortisol, thyroid hormone, and the sex steroids estrogen, progesterone, dehydroepiandrosterone and testosterone play in common mental disorders and pain sensitivity Psychoneuroimmunology in relation to age Sex differences and hormones in psychotropic drug metabolism in the elderly.

Dehydroepiandrosterone

Dehydroepiandrosterone, Volume 108, the latest release in the Vitamins and Hormones series first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this ...

Author: Gerald Litwack

Publisher: Academic Press

ISBN: 0128143622

Category: Science

Page: 459

View: 873

Dehydroepiandrosterone, Volume 108, the latest release in the Vitamins and Hormones series first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics such as Dehydroepiandrosterone Research: Past, Current and Future, Astrocyte Neuroprotection and Dehydroepiandrosterone, Mutation of HSD3B2 Gene and Fate of Dehydroepiandrosterone, Autophagy and Autophagic Cell Death: Uncovering New Mechanisms Whereby Dehydroepiandrosterone Promotes Beneficial Effects on Human Health, Dehydroepiandrosterone and Cardiovascular Disease, Dehydroepiandrosterone and Experimental Osteoarthritis, The Role of Dehydroepiandrosterone (DHEA) in Skeletal Muscle, Mechanism of Action of Dehydroepiandrosterone, and more. Focuses on the newest aspects of hormone action in connection with diseases Lays the groundwork for the focus of new chemotherapeutic targets Represents reviews on emerging areas in hormone action, cellular regulators and signaling pathways

Fantastic Voyage

“ Changes in serum cortisol with age in critically ill patients . ... “ Dehydroepiandrosterone ( DHEA ) and the aging brain : flipping a coin in the ...

Author: Ray Kurzweil

Publisher: Rodale

ISBN: 9781579549541

Category: Science

Page: 452

View: 462

Presents information about aging and illness, offers a program of diet and lifestyle choices allowing people to live longer and avoid sickness, and examines current and future roles for biotechnology and nanotechnology in health.