Development of the Adrenal Gland and Brain of the Spiny Mouse in Relation to Dehydroepiandrosterone dhea Biosynthesis

During development, DHEA has indeed been shown to have trophic effects on brain growth, and to have anti-glucocorticoid actions that diminish neurotoxicity and oxidative stress.

Author: Tracey Anne Quinn

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Page: 616

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During development, DHEA has indeed been shown to have trophic effects on brain growth, and to have anti-glucocorticoid actions that diminish neurotoxicity and oxidative stress. The studies summarised in Chapter 6 determined for the first time in this species, if DHEA is produced de novo in the developing brain of the spiny mouse. Expression of P450c17 and cytochrome-b5 (Cytb5) - the enzyme and accessory protein responsible for the synthesis of DHEA - together with expression of the glucocorticoid receptor (GR), were determined in the fetal brain at 25, 30, and 35 days of gestation, in the neonatal brain on the day of birth, and 80 days old adult brains by immunocytochemistry. Double-label immunofluorescence was used to determine co-localisation in neurons, astrocytes or oligodendrocytes. P450c17 bioactivity was determined using radioimmunoassay of conversion of pregnenolone to DHEA by explants of fetal, neonatal and adult brain. The fetal brain produced significantly more DHEA after 48 h in culture (22.46±2.0 ng/mg) than the adult brain (5.04±2.0 ng/mg; p

Adrenal Disorders

... and potential roles of dehydroepiandrosterone (DHEA) in prenatal and postnatal brain development: a re-examination using the spiny mouse.

Author: Alice C. Levine

Publisher: Humana Press

ISBN: 3319624709

Category: Medical

Page: 336

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This practical resource provides the latest evidence, management strategies and recommendations for the treatment of disorders of the adrenal glands, including related physiology, genetics and pharmacology. This book is divided into three thematic sections. The first covers adrenal physiology, presenting adrenal zonation and development, the regulation of steroidogenesis, and the pharmacology of glucocortisoids. Part two discusses the genetics and pathophysiology of a number of adrenal disorders, including autoimmune Addison’s disease, congenital adrenal hyperplasia, primary aldosteronism, adrenocortical tumors and hyperplasias, and pheochromocytomas and paragangliomas. The final section presents the latest diagnostic and management strategies for these disorders, addressing adrenal insufficiency, adrenal Cushing’s Syndrome and aldosteronism, among others. Over the past twenty years, our understanding of disorders of the adrenal glands has been altered and deepened. Providing a much-needed update to the literature, Adrenal Disorders: Physiology, Pathophysiology and Treatment will be an important resource for both academic and clinical endocrinologists working with the adrenal glands and managing patients with adrenal disorders.

Cumulated Index Medicus

Folia Med Cracov 1986 ; 27 ( 1-2 ) : 3-8 ( Eng . Abstr . ) 1985 Sep ; 106 ( 3 ) : 329–35 stimulation of cortisol synthesis . Davies E , et al .

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Category: Medicine

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