DHEA and the Brain

DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans.

Author: Robert Morfin

Publisher: CRC Press

ISBN: 0203301218

Category: Medical

Page: 226

View: 917

DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans. Chapter authors evaluate DHEA metabolism in tissues and organs, explore DHEA effects in the liver that may be of importance to the brain, and discuss recent findings regarding how DHEA is made in the brain. New perspectives about the neuropro

Development of the Adrenal Gland and Brain of the Spiny Mouse in Relation to Dehydroepiandrosterone dhea Biosynthesis

During development, DHEA has indeed been shown to have trophic effects on brain growth, and to have anti-glucocorticoid actions that diminish neurotoxicity and oxidative stress.

Author: Tracey Anne Quinn

Publisher:

ISBN:

Category:

Page: 616

View: 212

During development, DHEA has indeed been shown to have trophic effects on brain growth, and to have anti-glucocorticoid actions that diminish neurotoxicity and oxidative stress. The studies summarised in Chapter 6 determined for the first time in this species, if DHEA is produced de novo in the developing brain of the spiny mouse. Expression of P450c17 and cytochrome-b5 (Cytb5) - the enzyme and accessory protein responsible for the synthesis of DHEA - together with expression of the glucocorticoid receptor (GR), were determined in the fetal brain at 25, 30, and 35 days of gestation, in the neonatal brain on the day of birth, and 80 days old adult brains by immunocytochemistry. Double-label immunofluorescence was used to determine co-localisation in neurons, astrocytes or oligodendrocytes. P450c17 bioactivity was determined using radioimmunoassay of conversion of pregnenolone to DHEA by explants of fetal, neonatal and adult brain. The fetal brain produced significantly more DHEA after 48 h in culture (22.46±2.0 ng/mg) than the adult brain (5.04±2.0 ng/mg; p


Neuroactive Steroids in Brain Function Behavior and Neuropsychiatric Disorders

This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders.

Author: Abraham Weizman

Publisher: Springer Science & Business Media

ISBN: 9781402068546

Category: Medical

Page: 564

View: 875

This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain. It also suggests possible therapeutic approaches to the use of natural occurring or sinthetic neurosteroids. The contributors suggest that neuroactive steroids could have a role in clinical practice.



Dehydroepiandrosterone and Brain Aging

The work embodied in this book was carried out to find out whether administration of neuroprotective and anti-aging compound dehydroepiendrosterone (DHEA) at different ages of the animals prevents the delay of biochemical, molecular, ...

Author: Pardeep Kumar

Publisher: LAP Lambert Academic Publishing

ISBN: 9783846533895

Category:

Page: 108

View: 188

In recent years science and technology have made big steps, allowing us to greatly improve knowledge in basically every aspect of biology, culminating in the mapping of the human genome. However, although the brain is considered our most vital organ, the essence of personality and memory, much about the human brain still remains a mystery. Morphological analyses seemed to support the idea that senescence was accompanied by neuronal loss, particularly evident in the cortical and hippocampal structures. The work embodied in this book was carried out to find out whether administration of neuroprotective and anti-aging compound dehydroepiendrosterone (DHEA) at different ages of the animals prevents the delay of biochemical, molecular, structural and physiological alterations know to the neurological disease associated with aging. Based on study, the DHEA beneficial effects seemed to arise from their antioxidative, antiobesity, antilipofuscin and antilipidperoxidative actions.

Neurosteroids and Brain Function

This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field.

Author: Ronald J. Bradley

Publisher: Academic Press

ISBN: 9780123668462

Category: Medical

Page: 513

View: 798

International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field. Includes a historical overview of neurosteroid research Contains a chapter on neurosteroid biosynthesis and regulation Presents current methods of neurosteroid measurement and analysis Discusses neurosteroid function in both the normal and the pathological brain Chapters address the function of neurosteroid in: Stress, Receptor plasticity and function, Learning and Memory, Alcohol use, Depression

Dhea Supplements

GET YOUR COPY OF THIS BOOK NOW!

Author: Evelyn C. Cortez

Publisher:

ISBN: 9781976871757

Category:

Page: 61

View: 340

Uses, Dosage, Side Effects, Drug Interactions, Roles of DHEA in Brain, Biological Activities and Biochemistry Activities of DHEA Supplements and Pills. This book is everything you need to Know about DHEA supplement and pill which is useful for treating erectile dysfunction, improving heart health, lowering inflammation and fighting premature aging, boosting exercising performance, improving immunity, prevents infections and speed up healing, fast and effectively. The most important question on most people's mind is the uses, dosage, side effects, interaction with other drugs, roles in brain, biological and biochemistry activities of DHEA. DHEA has undergone research for use in a various selection of ailment which include lupus, erectile dysfunction, depression, adrenal insufficiency, cervical cancers, vaginal atrophy and weight loss just as Cialis, levitra and viagra is used for treating erectile dysfunction in men which has been responsible for treating impotence in 90% of men and has helped to save marriages and relationships. There are a lot of things that many of us do not know about this wonderful pill and how it can be used to effectively treat erectile dysfunction, improve immunity, fertility, brain power and detoxification, lupus, depression, adrenal insufficiency, cervical cancers, vaginal atrophy, weight loss, and many others. There are a lot of information on DHEA with a lot of fake information available online. DHEA is among the well-known treatment for men with erectile dysfunction and women with sexual problems, lupus, depression, adrenal insufficiency, cervical cancers, vaginal atrophy and weight loss which has helped to restore broken homes and brought happiness into relationships, it has treated more than 60 million men and women around the world. In this book, we shall be discussing the various functions of DHEA, roles of DHEA to the brain, some of the conditions it treats, related interactions, the side effects of DHEA and many more. Other things to learn include; Everything you need to know about DHEA supplement pills. Things you need to know before taking DHEA. DHEA dosage for treating the various health issues. The various side effects of DHEA. Biological and biochemistry activities of the DHEA pills or capsules. Various uses on how DHEA improves fertility in men and women, lupus, depression, adrenal insufficiency, cervical cancers, vaginal atrophy and weight loss. This book will likewise teach you DHEA interaction with other medicinal drugs. ...and many more! This book is the complete guide on dhea, dhea with, dhea-s, dhea keto 7, dhea herbal, dhea extract, dhea liquid, dhea booster, dhea gel, dhea powder erection pills, vascularity supplements l'Arginine, amino acid l'Arginine powder, zytenz, oxide nitric, viagra for men, supplements for muscle growth, Cialis pills for men, redwood supplement, Cialis pills for women, male enchantment pills, with proven information on how to cure erectile dysfunction, improve immunity, fertility, brain power and detoxification using DHEA to get your life back. GET YOUR COPY OF THIS BOOK NOW!

Neurosteroids

The aim of this Research Topic is to celebrate three decades of research on neurosteroids by gathering a bouquet of review papers and original articles from leading scientists in the flourishing field of neurosteroids.

Author: Hubert Vaudry

Publisher: Frontiers E-books

ISBN: 2889190781

Category:

Page:

View: 203

Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration did not affect the concentration of pregnenolone, dehydroepiandrosterone and their sulfate esters in the rat brain. These seminal observations led to the concept that the brain, in very much the same way as the adrenal cortex, testis, ovary and placenta, was capable of synthesizing steroids. These brain born steroids, called neurosteroids, have been found to exert a vast array of biological activities. A number of steroidogenic enzymes have now been identified in the central nervous system by immunohistochemistry and in situ hybridization, and the neuronal and hormonal mechanisms regulating the biosynthesis of neurosteroids have been partially elucidated. The aim of this Research Topic is to celebrate three decades of research on neurosteroids by gathering a bouquet of review papers and original articles from leading scientists in the flourishing field of neurosteroids.



Dehydroepiandrosterone DHEA and DHEA Sulfate Roles in Brain Function and Disease

Among the neuroactive steroids, dehydroepiandrosterone (3b-hydroxyandrost-5-ene-17-one, [DHEA]) and its sulfated metabolite DHEA sulfate (DHEAS) have been shown to be potent modulators of neural function, including neurogenesis, neuronal ...

Author: Tracey A. Quinn

Publisher:

ISBN:

Category: Medicine

Page:

View: 397

Among the neuroactive steroids, dehydroepiandrosterone (3b-hydroxyandrost-5-ene-17-one, [DHEA]) and its sulfated metabolite DHEA sulfate (DHEAS) have been shown to be potent modulators of neural function, including neurogenesis, neuronal growth and differentiation, and neuroprotection. Highlighting the potential health significance of DHEA and DHEAS in humans, serum concentrations decrease steadily with age, with lowest concentrations present at the time many diseases of aging and neurodegeneration become apparent. This temporal association has led to the suggestion that pathology associated with cognitive decline, age-related neurological disorders such as Alzheimer's disease, dementia, amyotrophic lateral sclerosis (ALS), and adult onset schizophrenia may, in part at least, be attributed to decreased secretion of DHEA. Animal studies suggest neuroprotective functions for DHEA and DHEAS through reduction of glutamate-induced excitotoxicity. Reduced myelin loss and reactive gliosis after spinal cord injury by DHEA treatment also suggest a role for DHEA in the treatment of white matter pathologies such as multiple sclerosis. In this chapter, we discuss the physiological roles of DHEA and DHEAS in the central nervous system (CNS), their potential as neuroprotective hormones with reference to documented effects on excitotoxicity and oxidative stress, and their anti-glucocorticoid actions during chronic stress. The potential for metabolic derivatives of DHEA, such as estrogens and testosterone on brain function, and their contribution to neurodevelopment and neurodegenerative conditions are also discussed.

Neuroendocrinology

The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers (prostate, breast, etc,).

Author:

Publisher: Elsevier

ISBN: 9780444537393

Category: Science

Page: 400

View: 869

Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience. Volumes 181 and 182 of Progress in Brain Research provide a rapid view of the major points presently discussed at biological and clinical levels. The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques. The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers (prostate, breast, etc,). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes). • The best researchers in the field provide their conclusions in the context of the latest experimental results • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered • Of great value for researchers and experts, but also for students as a background reference

Female Brain Gone Insane

The first book to specifically address the emotional issues of hormonal and brain chemistry imbalances Do you wake up every morning feeling flat and like you are going through the motions?

Author: Mia Lundin

Publisher: Simon and Schuster

ISBN: 0757395929

Category: Health & Fitness

Page: 248

View: 902

The first book to specifically address the emotional issues of hormonal and brain chemistry imbalances Do you wake up every morning feeling flat and like you are going through the motions? Feel wired but tired? Do you feel like it's all you can do to get through another day? Ambivalent or lackluster about life? Is your brain foggy and are you worried about your lack of sleep? If any of these questions pertain to you, you may feel like you have gone insane, but there is an emergency guidebook that can rescue you. Female Brain Gone Insane is the hands-on manual for women who feel like they are falling apart, losing it, or going "insane" and focuses on the emotional symptoms of hormone and brain chemistry imbalances associated with the combination of stress-filled lives and life transitions such as PMS, perimenopause, menopause, and postmenopause. Unlike other hormone books on the market, Female Brain Gone Insane is less focused on physiological changes such as bone loss and weight gain and instead tackles the legitimate panic and distress women feel as they experience symptoms associated with emotional and intellectual turmoil, including mood swings, loss of concentration and/or memory, and mental acuteness, to name a few. Women who have asked 'Why do I feel like I am losing it? 'How can I cope with the emotional changes I am experiencing?' and 'Will I ever feel like myself again?' will find real and compassionate help in this emergency guidebook. What's even more unique, is the author's contention that changes in the brain that affect a woman's mood, memory, concentration, and acuteness may not always be a hormone imbalance caused by menopause or other female-specific issues, as doctors often misdiagnose, but imbalances induced by the stress and anxiety levels associated with our fast-paced lifestyles that affect us at a deeper level. Bottom line, the key to a woman's well being is balanced brain chemistry, and Female Brain Gone Insane offers customizable solutions for every woman. Without lumping all women into one category, Female Brain Gone Insane helps each woman identify the symptoms of her particular emotional and psychological problems---be they depression, panic attacks, memory loss, or even acting out of character, and then offers support, information, and treatment so that she can rebalance herself. The core of the plan is to use bio-identical hormones (using the right hormone at the right time) and supplements carefully chosen to manipulate brain chemistry so that the body is happy again! Women will be liberated from their emotional turmoil with step-by-step, tailor-made rescue prescriptions based on the author's thriving practice of more than 3,000 satisfied patients. No more misdiagnoses or 'Band-aid' treatments such as antidepressants, birth-control pills, or even unnecessary surgeries Unique philosophy, accompanied with a combination of bio-identical hormones, nutritional supplements, good food, including targeted amino acid therapy, and lifestyle changes allows women to truly manipulate and support their brain chemistry Readers learn the basic science behind the intricate dance between their hormones and brain chemistry and are then encouraged to respect and identify their own emotional and physical symptoms Identifies the underlying causes of emotional symptoms and addresses women's unique bio-chemical composition with a new and unconventional approach to integrating bio-identical hormones, targeted amino acid therapy, and other nutritional supplements.

DHEA in Human Health and Aging

Nevertheless, and, ironically, in view of the fact that characterization of DHEA in rat brain led to the concept of neurosteroids, the synthesis of DHEA in ...

Author: Ronald Ross Watson

Publisher: CRC Press

ISBN: 1439838844

Category: Medical

Page: 472

View: 654

Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, an

Brain Fog

In women (but not in men), DHEA serves as a precursor (a building block) from which testosterone is formed. Many women can take DHEA and bring testosterone ...

Author: Binyamin Rothstein

Publisher: iUniverse

ISBN: 0595786790

Category: Medical

Page: 231

View: 441

What Is Brain Fog? Are you forgetting things that you used to remember easily? Do you sometimes feel like you're slogging through mud and just not as sharp and clear as you once were? Whether it is due to stress, fatigue, poor nutrition, a shift in hormones, toxins, food allergies, or an infectious disease, there are times when our mental faculties are less than optimal. You no longer need to be at the mercy of mental confusion again. Finally, you have the book that will give you the answers and solutions you need. As a pioneer in his field, Dr. Binyamin Rothstein has developed an indispensable resource guide to the workings of the brain and how you can maintain a sharp and clear mind throughout your life. THE LATEST ADVANCEMENTS IN MAINTAINING OPTIMAL BRAIN FUNCTION This book covers: Causes of brain fog and how to know which one may be affecting you The latest therapies and supplements to keep your brain fit and functional The most up-to-date information on hormones, hormone replacement therapy, food allergies, hypoglycemia and more Self-help measures to clear brain fog

The DHEA Breakthrough

With this comprehensive, accessible book, you can look forward to a longer, more satisfying, more healthful life! "I've used DHEA in my practice for five years and seen how it can help restore physiologic balance.

Author: Stephen Cherniske

Publisher: Ballantine Books

ISBN: 0307775011

Category: Health & Fitness

Page: 368

View: 749

DO YOU WANT . . . The high energy you enjoyed in your twenties and thirties? Protection against cancer, heart disease, diabetes, and osteoporosis? Renewed sexual appetite and vigor? To beat depression, boost your memory, and handle stress? To lose body fat while building up your lean muscle mass? DHEA can do all this and more! In The DHEA Breakthrough, biochemist Stephen Cherniske gives you all the information you need to take advantage of and maximize the extraordinary properties of this superhormone--safely and effectively. The DHEA Breakthrough contains the easy-to-implement DHEA Plan, including a diet designed for our "paleolithic" bodies, stress reduction techniques, and an exercise program that eases you into the next level of performance, no matter where you are now. With this comprehensive, accessible book, you can look forward to a longer, more satisfying, more healthful life! "I've used DHEA in my practice for five years and seen how it can help restore physiologic balance. That's close to a modern day miracle, and this book describes the breakthrough perfectly." --Jesse Hanley, M.D., Medical Director, Malibu Health and Rehabilitation

Hormones Brain and Behavior

DHEA interacts with other hormones and neurotransmitters. It is known for its powerful anti-GC action and has been suggested to protect the brain from the ...

Author:

Publisher: Academic Press

ISBN: 0128036087

Category: Medical

Page: 2474

View: 992

Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Comprehensive and updated coverage of a rapidly growing field of research Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior