Sex Steroids Effects on Brain Heart and Vessels

This book analyzes the effects of estrogens and progesterone on brain cells, the immune system, neuro inflammation, myelin formation and steroid receptor distribution, as well as their clinical impacts.

Author: Roberta Diaz Brinton

Publisher: Springer

ISBN: 3030113558

Category: Medical

Page: 294

View: 383

This book analyzes the effects of estrogens and progesterone on brain cells, the immune system, neuro inflammation, myelin formation and steroid receptor distribution, as well as their clinical impacts. It also explores the relationship between sex-steroid withdrawal and the development of brain symptoms such as hot flushes, sleep disorders, mood changes, depression and also cognitive disorders and dementia, as well as the effects of hormone menopause therapy on such symptoms and diseases. Starting with obstetrical history and cardiovascular risk in later life, the second part of the book examines the effects of estrogens and progestogens on vascular tissues, atherosclerosis and coronary heart diseases, as well as the impact of hormone replacement therapies on cardiovascular risks and mortality. This volume is a useful, clear and up-to-date tool for gynecologists, endocrinologists, neurologists and cardiologists, and serves as a valuable source of information for all physicians involved in women’s health.


Steroids and Brain Edema

Though, the volume contains the contributions of various experts - internists, neurochemists, neurologists, neuropathologists, neurosurgeons, pharmacologists, physiologists - who have added considerable experimental and clin ical evidence ...

Author: Hans J. Reulen

Publisher: Springer Science & Business Media

ISBN: 3642654487

Category: Medical

Page: 306

View: 334

The control of brain edema is still one of the major problems in surgical and conservative treatment of various cerebral lesions. Many attempts have been made to develop methods for reducing the high mortality associated with brain edema. Mter many years of using hypertonic solutions it can be stated that this type of therapy has not yielded satisfactory results. During recent years increasing evidence has been accumulated on the efficacy of steroids on brain edema. Steroids were reported to result in rapid relief of signs and symptoms of increased intracranial pressure and neurological dysfunction accompanying cerebral edema. It was the aim of this workshop to evaluate the effect of corticosteroids on brain edema as an advance in therapy. It was hoped that this could be achieved by a multi disciplinary approach. Though, the volume contains the contributions of various experts - internists, neurochemists, neurologists, neuropathologists, neurosurgeons, pharmacologists, physiologists - who have added considerable experimental and clin ical evidence on the action of steroids on brain edema. New pathophysiological aspects regarding the mechanisms underlying the formation and resolution of brain The effectiveness of corticosteroid therapy in various forms edema are presented. of clinical and experimental brain edema, e. g. accompanying brain tumors, head injury, spinal cord injury, cerebrovascular lesions, etc. as well as dosage and duration of treatment are critically discussed.

Neurosteroids and Brain Function

This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field.

Author: Ronald J. Bradley

Publisher: Academic Press

ISBN: 9780123668462

Category: Medical

Page: 513

View: 714

International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field. Includes a historical overview of neurosteroid research Contains a chapter on neurosteroid biosynthesis and regulation Presents current methods of neurosteroid measurement and analysis Discusses neurosteroid function in both the normal and the pathological brain Chapters address the function of neurosteroid in: Stress, Receptor plasticity and function, Learning and Memory, Alcohol use, Depression




Steroid Hormone Regulation of the Brain

The book starts with discussions that point out that steroid hormones not only function through intracellular steroid receptors, but possibly through steroid membrane actions as well. Studies to support this claim are presented.

Author: Kjell Fuxe

Publisher: Elsevier

ISBN: 1483158675

Category: Medical

Page: 424

View: 984

Steroid Hormone Regulation of the Brain focuses on the advancement of knowledge of the properties of brain steroid receptors and steroid target nerve cells, including the actions of gonadal steroids, adrenocortical steroids, and androgenic steroids on the brain. The selection features the work of authors who have inspiringly conducted extensive studies on the action of steroid hormones. The book starts with discussions that point out that steroid hormones not only function through intracellular steroid receptors, but possibly through steroid membrane actions as well. Studies to support this claim are presented. As to the action of steroid hormones on presynaptic transmitter mechanisms, the book suggests that adrenocortical and gonadal steroids can create alterations in noradrenaline, adrenaline, and dopamine levels and turnover within the hypothalamus and preoptic area. The effects of catecholestrogens on the brain are also elaborated. A contribution to this paper stresses that estrogens have antidopaminergic action in the extrapyramidal system. This idea is identified through a series of behavioral experiments and measurements of the levels of striatal acetylcholine. This selection is recommended to scientists interested in studying the effect of hormones on the brain.


Neuroactive Steroids in Brain Function Behavior and Neuropsychiatric Disorders

This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders.

Author: Abraham Weizman

Publisher: Springer Science & Business Media

ISBN: 9781402068546

Category: Medical

Page: 564

View: 413

This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain. It also suggests possible therapeutic approaches to the use of natural occurring or sinthetic neurosteroids. The contributors suggest that neuroactive steroids could have a role in clinical practice.


Steroids and the Nervous System

This volume covers emerging and intriguing topics related to research into steroids and the nervous system, with a major focus on glucocorticoids, non-classical mechanism of action, regulation of reproduction, steroids and glial cells, ...

Author: GianCarlo Panzica

Publisher:

ISBN:

Category: Medical

Page: 406

View: 450

This volume covers emerging and intriguing topics related to research into steroids and the nervous system, with a major focus on glucocorticoids, non-classical mechanism of action, regulation of reproduction, steroids and glial cells, behavioural effects and pathological correlations.

Neurosteroid Effects in the Central Nervous System

Our understanding of the ways that neuroactive steroids act in the brain has been increased by transgenic approaches, recombinant expression systems, higher resolution electrophysiological paradigms, and the development of technology to ...

Author: Sheryl S. Smith

Publisher: CRC Press

ISBN: 9780203508169

Category: Medical

Page: 408

View: 723

Our understanding of the ways that neuroactive steroids act in the brain has been increased by transgenic approaches, recombinant expression systems, higher resolution electrophysiological paradigms, and the development of technology to localize receptors. Recent behavioral studies examining the effects of steroids on mood, seizure susceptibility,

Steroids in Diseases of the Central Nervous System

Steroids in Diseases of the Central Nervous System deals with the current applications of steroids in a variety of clinical conditions; treatments are described for brain tumors, malignant glioma, head and spinal damage, Guillain-Barré ...

Author: Rudy Capildeo

Publisher: Wiley

ISBN:

Category: Medical

Page: 320

View: 141

Outstanding contributions present an overview of steroids, starting with their molecular biology, pharmacology, and immunology. Steroids in Diseases of the Central Nervous System deals with the current applications of steroids in a variety of clinical conditions; treatments are described for brain tumors, malignant glioma, head and spinal damage, Guillain-Barré syndrome, polymyositis, and other neurological diseases.

Possible Mechanics for the Steroid Antagonism of Lysergic Acid Diethylamide in the Rat

The ability of selected steroids to block changes in brain serotonin and catecholamine levels induced by administration of lysergic acid diethylamide (LSD) was investigated.

Author: Thomas M. Glenn

Publisher:

ISBN:

Category: LSD (Drug)

Page: 92

View: 840

The ability of selected steroids to block changes in brain serotonin and catecholamine levels induced by administration of lysergic acid diethylamide (LSD) was investigated. Brain levels of serotonin and catecholamines in the white rat were determined fluorometrically ten minutes after intraperitoneal injection of 40 mcg./Kg/ of LSD. Studies were also made on brain amine levels of animals treated with steroids (cortisone, prednisone, prednisolone, and progesterone), 1 mg. per day for three consecutive days prior to sacrificing. These animals were sacrificed one hour and forty minutes after the last steroid injection. The third group on which brain amine studies were made consisted of animals treated with steroids (1 mg. per day for three consecutive days); these animals were injected with lysergic acid diethylamide one and one half hours after the last steroid injection, and sacrificed after a ten minute interval. Steroids markedly reduced the serotonin elevation observed after LSD administration. No significant changes were observed in brain catecholamine levels in animals treated with lysergic acid diethylamide alone or with steroid-LSD combinations. These results indicate possible steroid-LSD competition for certain active sites in the brain.

CNS Neurotransmitters and Neuromodulators

As a volume in the series CNS Neurotransmitters and Neuromodulators, this text is destined to become a definitive reference.

Author: Trevor W. Stone

Publisher: CRC Press

ISBN: 9780849376337

Category: Science

Page: 256

View: 496

As a volume in the series CNS Neurotransmitters and Neuromodulators, this text is destined to become a definitive reference. Well-known international authors have contributed up-to-date reviews covering a wide-range of interdisciplinary aspects of neuroactive steroid function. Specifically, this volume includes chapters dealing with the expression and properties of steroid receptors in the central nervous system (CNS); steroid interactions with amino acids, amines, and growth factors; electrophysiology; hypothalamic and feeding control; and the extremely topical issue of steroid influences on sexual differentiation of the brain. Neuroactive Steroids is an indispensable reference work for any researcher involved with steroids in the CNS, particularly in the areas of physiology, anatomy, neuropharmacology, neurochemistry, psychiatry, and molecular biology. In addition, it provides the perfect one-stop introduction for students.




Steroid Acyl Transferase Activity in the Mammalian Brain

This thesis investigates steroid fatty acid esters (which may have a possible role in myelination of the central nervous system) in mammalian brain.

Author: Andrea J. Smith

Publisher:

ISBN:

Category: Brain chemistry

Page: 474

View: 575

This thesis investigates steroid fatty acid esters (which may have a possible role in myelination of the central nervous system) in mammalian brain. While these conjugates are abundant in brain tissue, little is known about their biological role. When measuring steroid acyl transferase activity, the optimum substrate concentration was found to vary significantly between the sheep and rat brain. Results also indicated that different enzymes may act to esterify different steroid substrates.