Neuroactive Steroids in Brain Function Behavior and Neuropsychiatric Disorders

Chapter 11 Dehydroepiandrosterone, as Endogenous Inhibitor of Neuronal Cell Apoptosis: Potential ... (DHEA) is synthesized in the adrenals and the brain.

Author: Abraham Weizman

Publisher: Springer Science & Business Media

ISBN: 9781402068546

Category: Medical

Page: 564

View: 277

This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain. It also suggests possible therapeutic approaches to the use of natural occurring or sinthetic neurosteroids. The contributors suggest that neuroactive steroids could have a role in clinical practice.

Sex Hormones in Neurodegenerative Processes and Diseases

In humans, DHEA is one of the most abundant hormones synthesized and ... Dehydroepiandrosterone (DHEA) and DHEA Sulfate: Roles in Brain Function and Disease ...

Author: Gorazd Drevensek

Publisher: BoD – Books on Demand

ISBN: 1789230144

Category: Medical

Page: 358

View: 426

The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.

Neurotransmitters Drugs and Brain Function

13.5 but the synthetic pathways are not well established . PREG and DHEA are known as 3B - hydroxy - A5 - steroids and are also found in peripheral glands ...

Author: Roy Webster

Publisher: John Wiley & Sons

ISBN: 9780471978190

Category: Medical

Page: 544

View: 532

Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.

The Path to Phenomenal Health

Low DHEA levels decrease libido, mood, energy and brain function. Elevated DHEA reduces the symptoms of menopause without ingesting synthetic estrogen and ...

Author: Sam Graci

Publisher: John Wiley & Sons

ISBN: 9780470739396

Category: Health & Fitness

Page: 226

View: 371

A comprehensive and inspiring look at the keys to revamping your tired lifestyle. Sam offers his best tips for renewing, restoring, revitalizing and rejuvenating your life with his trademark personal style. This book will become the one title anyone needs to feel better needs, as it covers mind, body and spirit. Full of tips, lists and do-able suggestions as well as personal stories and experiences, The Path to Phenomenal Health is a great read, sure to help you get on the right track with your health, once and for all.

Neurosteroids and Brain Function

... dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEAS), ... idea that certain steroids might be synthesized de novo in the CNS, ...


Publisher: Academic Press

ISBN: 0080544231

Category: Science

Page: 208

View: 458

International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field. Includes a historical overview of neurosteroid research Contains a chapter on neurosteroid biosynthesis and regulation Presents current methods of neurosteroid measurement and analysis Discusses neurosteroid function in both the normal and the pathological brain Chapters address the function of neurosteroid in: Stress Receptor plasticity and function Learning and Memory Alcohol use Depression

Hormones and Brain Function

The quantitative importance of this corticoid synthetic pathway has to be assessed. ... In the placenta extensive conversion of dehydroepiandrosterone and ...

Author: K. Lissak

Publisher: Springer Science & Business Media

ISBN: 1468420070

Category: Medical

Page: 530

View: 260

The International Society of Psychoneuroendocrinology organized its second congress in Budapest between 1 and 3 July, 1971. The sudden death on the 27th of July, 1970, of Professor Max Reiss, the President of the Society, nearly caused a break in the preparation ofthe Congress, but with the invaluable help of Professor Donald H. Ford, Treasurer and Acting President, and Professor Francesca Brambilla, Secretary of the Society, the Organizing Committee surmounted the difficulties. The Organizing Committee of the Congress set out five main topics discussed in five sections by invited lecturers and collective papers by regis tered discussants. Technically, the Congress was organized by the Hungarian Physiological Society in cooperation with the Federation of Hungarian Medical Societies in the building of the Hungarian Academy of Sciences. Thanks to the generosity of the Medical Section of the Hungarian Academy of Sciences we are able to publish the Pro ceedings of the Congress by the Publishing House of the Hungarian Academy of Sciences jointly with Plenum Press, New York. The Congress was sponsored by the International Society of Psychoneuroendo crinology, the Hungarian Academy of Sciences, the Hungarian Pharmaceutical Industry, the Factory of Electronic Measuring Instruments, the Upjohn Co., Kalamzoo, Michigan and the Wellcome Research Laboratory, Langley Court, Backenhom, Kent, England. On behalf of the Organizing Committee may I ex press our grateful thanks for their generous assistance which, despite many difficulties, made the successful organization of an international congress possible.

Hormones in Neurodegeneration Neuroprotection and Neurogenesis

This book is written by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair.

Author: Achille G. Gravanis

Publisher: John Wiley & Sons

ISBN: 3527633979

Category: Science

Page: 404

View: 732

As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.

DHEA and the Brain

... the benefits of DHEA in preventing cancer, obesity, abnormal glucose metabolism, excessive appetite, ageing as well as deterioration of brain function ...

Author: Robert Morfin

Publisher: CRC Press

ISBN: 1134475756

Category: Medical

Page: 226

View: 406

DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans. Chapter authors evaluate DHEA metabolism in tissues and organs, explore DHEA effects in the liver that may be of importance to the brain, and discuss recent findings regarding how DHEA is made in the brain. New perspectives about the neuropro

Bottom Line s Power Aging The Revolutionary Program to Control the Symptons of Aging Naturally

We've already discussed vitamin E, but we should mention it again as being very important in maintaining brain function. Vitamin E (not synthetic) slows ...

Author: Gary Null

Publisher: Stranger Journalism

ISBN: 0887234453

Category: Aging

Page: 382

View: 904

A leader in the field of alternative health presents his program to control the symptoms of aging, discussing the processes and factors that contribute to aging, the hormonal keys to health, and a diet and exercise regimen.

Compendium Surviving Cancer Natural Allopathic Medicine

[2] All tissues rely on DHEA for optimal function though, especially the brain, so it is very important for us to find a way to naturally raise DHEA levels.

Author: Dr. Mark Sircus

Publisher: Lulu Press, Inc

ISBN: 1312666986

Category: Health & Fitness


View: 478

This 2,500 page cancer compendium will offer you and your family most of the information you will need to make informed choices about cancer care. This compendium will teach you about natural oncology. It is a medical book, in understandable language, about a new form of medicine called Natural Allopathic Medicine.

The New Feminine Brain

Progesterone may play a role in repairing and replacing the protective ... estrogens or synthetic progesterone do not match the brain cell receptors and ...

Author: Mona Lisa Schulz

Publisher: Simon and Schuster

ISBN: 1439104751

Category: Self-Help

Page: 480

View: 811

Ever wonder why most women can handle the kids and careers and the renovation but men can concentrate on either the newspaper or a game on TV? This is because female brains have more interconnections that allow them to multi-task and split their attention. The New Feminine Brain is the first book by a medical doctor, who is also a psychiatrist and a brain expert, to show how modern life challenges are physically rewiring the brain and to address the particular challenges that women face as a result. The female brain today is not your grandmother's brain - it has even more connections and skills, but with that can come more physical problems, including an increase in attention and memory deficits and chronic mood and health conditions. The New Feminine Brain combines the insights of Dr Schulz's research and stories of clinical experience as a neuropsychiatrist treating people with tough brain disorders with unique self-help and expert health advice. Readers will discover and cultivate their special genius and intuitive style with provocative self-tests, so they can hear and heal their depression, anxiety, attention, memory, and other brain problems. 'Rewiring' exercises, herbs and nutritional supplements will improve their physical, psychological and emotional health.

Hormones Brain and Behavior

The source and function of DHEA will be discussed in greater detail in a later ... brain-derived neurotrophic factor (BDNF) is synthesized in neurons of HVC ...


Publisher: Academic Press

ISBN: 0128036087

Category: Medical

Page: 2474

View: 305

Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Comprehensive and updated coverage of a rapidly growing field of research Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior

Female Brain Gone Insane

The first book to specifically address the emotional issues of hormonal and brain chemistry imbalances Do you wake up every morning feeling flat and like you are going through the motions?

Author: Mia Lundin

Publisher: Simon and Schuster

ISBN: 0757395929

Category: Health & Fitness

Page: 248

View: 574

The first book to specifically address the emotional issues of hormonal and brain chemistry imbalances Do you wake up every morning feeling flat and like you are going through the motions? Feel wired but tired? Do you feel like it's all you can do to get through another day? Ambivalent or lackluster about life? Is your brain foggy and are you worried about your lack of sleep? If any of these questions pertain to you, you may feel like you have gone insane, but there is an emergency guidebook that can rescue you. Female Brain Gone Insane is the hands-on manual for women who feel like they are falling apart, losing it, or going "insane" and focuses on the emotional symptoms of hormone and brain chemistry imbalances associated with the combination of stress-filled lives and life transitions such as PMS, perimenopause, menopause, and postmenopause. Unlike other hormone books on the market, Female Brain Gone Insane is less focused on physiological changes such as bone loss and weight gain and instead tackles the legitimate panic and distress women feel as they experience symptoms associated with emotional and intellectual turmoil, including mood swings, loss of concentration and/or memory, and mental acuteness, to name a few. Women who have asked 'Why do I feel like I am losing it? 'How can I cope with the emotional changes I am experiencing?' and 'Will I ever feel like myself again?' will find real and compassionate help in this emergency guidebook. What's even more unique, is the author's contention that changes in the brain that affect a woman's mood, memory, concentration, and acuteness may not always be a hormone imbalance caused by menopause or other female-specific issues, as doctors often misdiagnose, but imbalances induced by the stress and anxiety levels associated with our fast-paced lifestyles that affect us at a deeper level. Bottom line, the key to a woman's well being is balanced brain chemistry, and Female Brain Gone Insane offers customizable solutions for every woman. Without lumping all women into one category, Female Brain Gone Insane helps each woman identify the symptoms of her particular emotional and psychological problems---be they depression, panic attacks, memory loss, or even acting out of character, and then offers support, information, and treatment so that she can rebalance herself. The core of the plan is to use bio-identical hormones (using the right hormone at the right time) and supplements carefully chosen to manipulate brain chemistry so that the body is happy again! Women will be liberated from their emotional turmoil with step-by-step, tailor-made rescue prescriptions based on the author's thriving practice of more than 3,000 satisfied patients. No more misdiagnoses or 'Band-aid' treatments such as antidepressants, birth-control pills, or even unnecessary surgeries Unique philosophy, accompanied with a combination of bio-identical hormones, nutritional supplements, good food, including targeted amino acid therapy, and lifestyle changes allows women to truly manipulate and support their brain chemistry Readers learn the basic science behind the intricate dance between their hormones and brain chemistry and are then encouraged to respect and identify their own emotional and physical symptoms Identifies the underlying causes of emotional symptoms and addresses women's unique bio-chemical composition with a new and unconventional approach to integrating bio-identical hormones, targeted amino acid therapy, and other nutritional supplements.

Translational Research in Traumatic Brain Injury

The synthetic progestin medroxyprogesterone acetate (Provera) is not ... of dehydroepiandrosterone sulfate improves recovery of function after traumatic ...

Author: Daniel Laskowitz

Publisher: CRC Press

ISBN: 1466584920

Category: Medical

Page: 412

View: 628

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

The Effects of Estrogen on Brain Function

There is also little evidence to suggest that DHEAS or DHEA has positive effects on cognitive function in postmenopausal women ( Huppert and Van Niekerk ...

Author: Natalie L. Rasgon

Publisher: JHU Press

ISBN: 9780801882821

Category: Health & Fitness

Page: 170

View: 248

This timely volume reviews current data on the effects of estrogen on the central nervous system -- including the effects of estrogen on mood, cognition, and brain metabolism -- and provides guidelines for clinical practice and future research. Experts from the fields of psychiatry, pharmacology, neurology, and geriatrics collaborate to clarify the known risks and benefits of hormone therapy and explore questions that remain to be elucidated.

Genetics of Steroid Biosynthesis and Function

A confounding factor is that DHEA and pregnenolone levels may be significantly elevated or reduced in brain disease, including anxiety and chronic fatigue ...

Author: J.I. Mason

Publisher: CRC Press

ISBN: 0203301498

Category: Medical

Page: 500

View: 552

Steroids are among the most widely prescribed drugs for humans, and steroid signaling pathways are present in vertebrates, plants, insects and fungi, presenting new avenues for biotechnological intervention. Genetics of Steroid Biosynthesis and Function focuses on the genetic and cellular aspects of mammalian steroid hormones with particular attent

Traumatic Brain Injury

On a more functional level, androgen precursors have been demonstrated to affect ... In one study, dehydroepiandrosterone (DHEA) administered 1 week ...

Author: Mark J. Ashley

Publisher: CRC Press

ISBN: 143984982X

Category: Medical

Page: 1084

View: 525

Since the bestselling second edition was published almost a decade ago, the field of brain injury treatment has undergone tremendous change, largely impacting access to treatment. But, while the healthcare marketplace has evolved, the needs of brain injury victims remain the same. With updated and expanded clinical coverage, Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition delineates a broad spectrum of advanced theoretical clinical constructs and detailed diagnostic and treatment interventions for traumatic brain injury. Details Specific Diagnostic and Treatment Approaches for Nearly All Aspects of Dysfunction Observed Following Brain Injury With contributions from more than 50 authorities in both academia and industry, this highly respected text stands apart as a clinical guide to rehabilitative treatment of persons with traumatic brain injury following the acute phase of treatment. It provides a concise source of information about the scientific and therapeutic realms involved in the rehabilitation of a person with traumatic brain injury, specifically as they relate to persistent deficits. The book also details long-term consequences of brain injury and effective approaches to vocational rehabilitation and case management. Widening coverage from the previous edition, this book includes details on: Metabolic and bioenergetic factors in brain injury Neuroendocrine dysfunction following brain injury Blast injury Ethical issues in treatment of brain injury Neuropharmacological and neuropsychological interventions following brain injury Interventions for the minimally conscious patient Dietary and exercise considerations after brain injury Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management, Third Edition is a complete source of pharmacological, anatomical, and physiological information for basic therapeutic rationales that are often not well understood in the field. It is an ideal reference for both new and experienced clinicians.